Navnet VX2 RDP-149 and Standard Horizon GX2100 AIS

Yes it should.
You will need to make sure you have updated software in the vx2, (1.08 or higher) and you will need a 6 pin data cable from Furuno (part # 000-154-054).
Baud rate must be set to 38400bps.
There is actually a wiring diagram of the Standard Horizon website showing the connection to the NavNet vx2.